Argentina has contributed many distinguished doctors, scientists and inventors to the world, including three Nobel Prize laureates in sciences. Argentines have been responsible for major breakthroughs in world medicine; their research has led to significant advances in wound-healing therapies and in the treatment of heart disease and several forms of cancer. Domingo Liotta designed and developed the first artificial heart successfully implanted in a human being in 1969. René Favaloro developed the techniques and performed the world's first ever coronary bypass surgery, and Francisco de Pedro invented a more reliable artificial cardiac pacemaker. Bernardo Houssay, the first Latin American awarded with a Nobel Prize in the Sciences, discovered the role of pituitary hormones in regulating glucose in animals; César Milstein did extensive research in antibodies; Luis Leloir discovered how organisms store energy converting glucose into glycogen and the compounds which are fundamental in metabolizing carbohydrates. A team led by Alberto Taquini and Eduardo Braun-Menéndez discovered angiotensin in 1939, and was the first to describe the enzymatic nature of the renin-angiotensin system and its role in hypertension. The Leloir Institute of biotechnology is among the most prestigious in its field in Latin America and in the world. Dr. Luis Agote devised the first safe method of blood transfusion; Enrique Finochietto designed operating table tools such as the surgical scissors that bear his name and a surgical rib-spreader. They have likewise contributed to bioscience in efforts like the Human Genome Project, where Argentine scientists have successfully mapped the genome of a living being, a world first.